Doramectin yog derivative ntawm ivermectin thiab macrocyclic lactone. Nws yog ib qho tshuaj tua kab mob uas muaj zog heev uas qhia txog kev ua haujlwm tawm tsam ntau yam ntawm nematodes thiab arthropods. Doramectin ua haujlwm los ntawm inhibiting lub peev xwm ntawm cov paj hlwb lossis cov leeg hlwb, uas ua rau tuag tes tuag taw thiab tuag ntawm cov cab.
Doramectin pab tsiaj li cas?
Doramectin ua rau muaj zog permeability nyob rau hauv lub paj hlwb ntawm nematodes.Nws kuj ua rau kev hloov pauv hauv cov hlwb neuromuscular hauv arthropods. Cov tshuaj no nce kev tso tawm ntawm gamma-aminobutyric acid hauv presynaptic neurons. Cov kua qaub no ua haujlwm ua ib qho inhibitory neurotransmitter uas thaiv cov stimulation ntawm postsynaptic neurons hauv nematodes lossis arthropods. Cov tshuaj no tsis muaj tshuaj lom rau cov tsiaj txhu vim nws tsis muaj cov tshuaj chlorine raws glutamate-dependent. Qhov no yog vim hais tias cov tshuaj no tsis hla cov ntshav-hlwb barrier los yog nws tau sau nyob rau hauv me me.