Yogfenbendazoleib tug antiparasitic?
Fenbendazole yog ib qho tshuaj tiv thaiv kab mob uas siv rau kev kho mob plab hnyuv thiab ua pa helminth kab mob hauv ntau hom tsiaj, xws li miv, nyuj, dev, tshis, nees, nqaij qaib, yaj thiab npua. Nws muaj txiaj ntsig zoo hauv kev kho cov kab mob xws li Bunostomia, Schistosoma haematobium, Nematodes, E. coli, Strongyloides, thiab Schistosoma pulmonarum.
Fenbendazole belongs rau benzimidazole carbamate pawg ntawm cov tshuaj. Nws muaj broad-spectrum kev ua ub no tiv thaiv ob leeg paub tab thiab tsis paub qab hau nematodes thiab tapeworms. Fenbendazole ua haujlwm los ntawm inhibiting glucose uptake. Qhov no depletes cov cab glycogen reserves, ua rau nws tuag.
Lub mechanism ntawm kev txiav txim ntawm fenbendazole
Cov txheej txheem ntawm kev ua ntawm fenbendazole tsuas yog tua cov kab mob los ntawm kev cuam tshuam nrog lawv lub zog metabolism. Ua ntej, nws khi rau -microtubule proteins hauv cov kab mob cab thiab inhibits kev tsim ntawm microtubules. Microtubules yog ib feem tseem ceeb ntawm cytoskeleton thiab koom nrog hauv kev faib cell, kev saib xyuas ntawm morphology thiab kev thauj mus los ntawm cov khoom. Fenbendazole thaiv cov polymerization ntawm microtubules, ua rau tsis muaj peev xwm ntawm cov kab mob cab kom faib thiab ua haujlwm zoo. Qhov thib ob, fenbendazole kuj cuam tshuam nrog cov kab mob parasite uptake ntawm qabzib, uas tuaj yeem ua rau cov kab mob tsis muaj zog thiab thaum kawg ua rau nws tuag. Los ntawm cov txheej txheem no, fenbendazole muaj txiaj ntsig zoo hauv kev tua ntau yam kab mob, suav nrog nematodes thiab tapeworms.
Dab tsi yog Fenbendazole siv rau hauv cov tsiaj?
dev thiab miv
Fenbendazole feem ntau yog siv los kho cov kab mob hauv plab, nrog rau cov kab mob sib kis, cov kab mob sib txuas, cov kab mob thiab qee cov kab mob.
Nees.
Nyob rau hauv cov tshuaj equine, fenbendazole yog siv los tswj roundworms, pinworms thiab roundworms.
nyuj thiab tshis
Fenbendazole muaj txiaj ntsig zoo tiv thaiv kab mob ntsws, kab mob plab thiab kab mob plab hnyuv hauv ruminants.
Kev Phem Tsis Zoo
Siv nyob rau hauv cov tshuaj noj, feem ntau tsis muaj kev phiv loj heev. Txawm li cas los xij, kev tsis haum tshuaj yuav tshwm sim tom qab kev tso tawm antigens los ntawm cov kab mob tuag, tshwj xeeb tshaj yog thaum noj tshuaj ntau. Qee zaum ntuav tau pom thaum muab rau dev lossis miv. Leukopenia tau raug tshaj tawm hauv cov xwm txheej tsawg.
Cov kev ceev faj
Contraindicated nyob rau hauv nees thiab lactating nyuj thiab yaj.
Cov khoom no tej zaum yuav muaj teratogenic thiab embryotoxic teebmeem thiab yog nruj me ntsis contraindicated nyob rau hauv thaum ntxov cev xeeb tub.
Rau dev, miv thiab lwm yam tsiaj, cov nyhuv ntawm kev siv ib zaug yuav tsis pom tseeb, yuav tsum tau siv tsis tu ncua rau 3 hnub.